University of Minnesota

Study Synopses

These systematic summaries cover the early epidemiological studies and prevention trials, begun mainly before the mid-1970s. Submissions are welcome of other relevant study descriptions from that early period, along with additions or corrections to existing summaries.

References to the defining publication of each of these early studies are found in table form by clicking here.

Title Year(s) Principal Investigator
Alameda County Study 1964 Breslow, Lester
Albany Cardiovascular Health Center Study 1953 - 1981 Doyle, Joseph
Anti-Coronary Club Trial 1957 Christakis, G.
Atherosclerosis Risk in Communities Study (ARIC) 1986 The ARIC Investigators
Belgian Bank Study 1964 Kornitzer, Marcel
Bierenbaum St. Vincent’s Hospital Study 1959 Bierenbaum, M.L.
Bogalusa Heart Study 1972 Berenson, Gerald
British Doctors Study 1951 - 2001 Doll, Richard
British MRC Soya-Bean Oil Trial 1960 British Medical Research Council
Busselton Heart Study 1966 Welborn, T.A.
California Longshoremen Study 1951 - 1973 Paffenbarger, Jr., Ralph
Charleston Heart Study 1960 Boyle, Jr., Edwin
Chicago Heart Association Detection Project in Industry 1967 Stamler, Jeremiah
Chicago Peoples Gas Company Study 1958 Stamler, Jeremiah
Chicago Western Electric Study 1957 Paul, Oglesby
Cooperative Study of Lipoproteins and Atherosclerosis 1952 Cooperative Lipoprotein Study Group
Copenhagen City Heart Study 1976 Schnohr, Peter
Coronary Drug Project (CDP) 1966 Coronary Drug Project Research Group (Stamler, J. chariman)
Coronary Heart Disease in Young Adults. A Multidisciplinary Study 1946 - 1976 White, Paul Dudley
DuPont Company Study 1956 Pell, Sydney
European Myocardial Infarction Registers 1968 WHO Collaborating Investigators in Europe
Evans County Cardiovascular and Cerebrovascular Study 1960 - 1995 Hames, Curtis
Finnish Mental Hospital Trial 1959 - 1971 Turpeinen, O.
Finnish Social Insurance Institution Study 1966 Aromaa, A.
Framingham Heart Study 1948 Dawber, T. Royle
Glostrup Study 1964 Hagerup, L.M.
Goteborg Multifactorial Primary Prevention Trial 1970 Wilhelmsen, Lars
Goteborg Study of Men Born in 1913 1963 Tibblin, Gösta
Harvard Alumni Study 1962 Paffenbarger, Jr., Ralph
Helsinki Policemen Study 1966 Pyörälä, Kalevi
Hirosaki University Study 1950 Sasaki, Naosuke
Hisayama Study 1961 Sadoshima, S.
Honolulu Heart Study 1965 Kagan, Abraham
Hypertension Detection and Follow-up Program (HDFP) 1970 Hypertension Detection and Follow-up Program Cooperative Group
INTERSALT Study 1984 - 1997 Stamler, Jeremiah
Israel Ischemic Heart Disease Study 1963 Goldbourt, Uri
Johns Hopkins Precursors Study 1948 Thomas, Caroline Bedell
Korean Soldiers Study 1951 Enos, Jr., William
Lipid Research Clinics (LRC) Coronary Primary Prevention Trial 1973 Lipid Research Clinics Program
Lipid Research Clinics (LRC) Program Prevalence Study 1973 The Lipid Research Clinics Program Epidemiology Committee
London Transport Workers Study 1949 - 1952 Morris, Jeremy
Los Angeles Heart Study 1949 Chapman, J.
Malmö Study 1970 Lannerstad, O.
Minnesota Business and Professional Men’s Study 1947 - 1983 Keys, Ancel
Minnesota Heart Health Program 1980 Blackburn, Henry
Morrison Diet-Heart Study 1946 Morrison, Lester M.
Multifactorial CVD Prevention Trial in Helsinki Businessmen 1964 Standberg, T.E.
Multiple Risk Factor Intervention Trial (MRFIT) 1972 Multiple Risk Factor Invervention Trial Group
Muscatine Study 1971 Lauer, Ronald M.
National Diet Heart Study 1962 National Diet Heart Group
NiHonSan Study 1965 NIHONSAN Study Group
North Karelia Project 1972 - 1997 Puska, Pekka
Ohasama Study 1965 Imai, Yutaka
Olmsted County Study 1965 Connolly, Daniel C.
On the Trail of Heart Attacks in Seven Countries Field Notes Blackburn, Henry
Osaka Medical Center Study 1956 Komachi, Yoshio
Oslo (Leren) Diet-Heart Study 1957 Leren, Paul
Oslo Study (Cohort) 1972 - 1993 Leren, Paul
Oslo Study of Diet and Anti-Smoking Advice 1972 Hjermann, Ingvar
Paris Prospective Study 1967 - 1975 Richard, Jacques
Pawtucket Heart Health Program 1980 Carleton, Richard
Program on Surgical Control of Hyperlipidemias (POSCH) 1975 Buchwald, Henry
Puerto Rico Cardiovascular Disease Study 1965 Garcia-Palmieri, M.R.
Renfew/Paisley (Midspan) Study 1972 Hawthorne, Victor
Scottish Society of Physicians Clofibrate Trial 1964 Research Committee of the Scottish Society of Physicians
Seal Beach Study 1964 Cutler, J.
Seven Countries Study 1957 Keys, Ancel
Seven Countries Study in Japan 1958 Kimura, Noboru
Shiga University Studies 1980 Ueshima, Hirotsugu
South Africa Study 1954 Bronte-Stewart, Brian
Stanford Community Trials 1972 - 1992 Farquhar, John
Stockholm Prevention Trial with Clofibrate and Niacin 1972 Carlson, L.A.
Stockholm Study 1961 Carlson, L.A.
Tanno and Sobetsu Studies 1975 Limura, Osamu
Tecumseh Community Health Study 1959 - 1973 Epstein, Frederick
Tokelau Island Studies 1968 - 1982 Prior, Ian
U.S. Railroad Study 1957 Taylor, Henry Longstreet
United Airlines Study 1966 Krasno, L.R.
University Group Diabetes Program (UGDP) 1960 University Group Diabetes Program Group
VA Cooperative Study on Atherosclerosis 1962 Veterans Administration Cooperative Study Group
VA Cooperative Study on Hypertension 1962 Freis, Edward
Wadsworth Veterans Administration Domiciliary Hospital Study 1959 Dayton, S.
Western Collaborative Group Study 1960 R.H. Rosenman was P-I for the incidence study (1960-1969). D.R. Ragland and R.J.Brand were the P-I's for the mortality study (1982-1983).
Whitehall I 1967 Marmot, Michael
Whitehall II 1987 Marmot, Michael
WHO Collaborative Trial of Multifactorial Prevention 1970 WHO European Collaborative Group (Rose, G. chairman)
WHO Cooperative Clofibrate Trial 1962 Committee of Principal Investigators (M. Oliver Chairman)
WHO Multicenter, Multi-factor Coronary Rehabilitation Trial 1983 N/A
Yugoslavia Cardiovascular Disease Study 1964 Kozarevic, D.