Ancel Keys and Mark Hegsted Letters 1986
Toward the end of their lives, Mark Hegsted and Ancel Keys got closer together about the shape of the relation of dietary cholesterol and serum cholesterol. They were always together on the relation of dietary oleic acid and serum cholesterol. Their careful study designs allowed them to see that, other factors constant, oleic acid was neutral in effect on serum cholesterol. Mattson and Grundy held out that oleic lowered serum cholesterol, whereas their design only showed a lowering effect as replacement for saturated fatty acids. This they misinterpreted as an independent lowering effect like PUFA. These letters show their postures along with mutual respect.
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Hegsted: 1986-03-03 Letter Hegsted-Keys