Alan T. Hirsch, MD
Adjunct Professor, EpiCH
1980 M.D., University of California, San Francisco, CA
1976 B.A., Harvard College, Cambridge, MA
Teaches:
PubH 6301: Fundamentals of Clinical Research
Research Interests:
1. New pharmacotherapeutic and biobehavioral treatments for peripheral vascular diseases: Principal investigator for the design and performance of single-site and multi-center clinical trials to evaluate the efficacy of interventions to improve clinical outcomes for acute and chronic peripheral arterial occlusive and venous occlusive diseases.
2. Assessment and pharmacological intervention for individuals with
"intermediate" cardiovascular risk.
3. Community-based peripheral arterial disease detection, systemic
risk and claudication treatment interventions, and global vascular
outcome assessments.
4. Assessment of the impact of clinician and public education
regarding peripheral arterial and venous diseases.
>>> Research Projects
Recent Publications:
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Belch JJF, Topol EJ, Agnelli G, Bertrand M, Califf RM, Clement DL, Creager MA, Easton JD, Gavin JR, Greenland P, Hankey G, Hanrath P, Hirsch AT, Meyer J, Pearson TA, Smith SC, Sullivan F, Weber MA. Critical Issues in Peripheral Arterial Disease Detection and Management: A Call to Action. Arch Int Med 2003:163:884-892
Mohler ER, Hiatt WR, Olin J, Wade M, Jeffs R, Hirsch AT. Treatment of Intermittent Claudication with Oral Beraprost Sodium, an Orally Active Prostaglandin I2 Analogue: A Double-Blind, Randomized, Controlled Trial. J Amer Coll Cardiol 2003;41:1679-1686
Rajagopalan S, Mohler E 3rd, Lederman RJ, Saucedo J, Mendelsohn FO, Olin J, Blebea J, Goldman C, Trachtenberg JD, Pressler M, Rasmussen H, Annex BH, Hirsch AT. Regional angiogenesis with vascular endothelial growth factor (VEGF) in peripheral arterial disease: Design of the RAVE trial. Am Heart J 2003;145(6):1114-8
Creager MA, Hirsch AT, Cooke JP, Olin JW, Jaff MR, Rooke T, Halperin JL. On behalf of the Working Group on Fellowship Training in Vascular Medicine. Postgraduate Training in Vascular Medicine: Proposed Requirements and Standards. Vascular Medicine 2003;8:47-52
Hirsch AT. Vascular Disease, Hypertension & Prevention Highlights: “From Endothelium to Clinical Events”. J Amer Coll Cardiology 2003: 377(42):375–93
McDermott MM, Greenland P, Hahn E, Hirsch A, Pearce WH, Cella D, Ockene JK, Brogan D, Criqui MH, Lipsky M, Odom L, Hanley K, Kahn S. Factors associated with enhanced physician response rates to a mailed questionnaire. Health Marketing Quarterly 2003; 20(4):27-42.
Hirsch AT, Gloviczki P, Drooz A, Lovell M, and Creager MA on behalf of the Trustees of the Vascular Disease Foundation. The Mandate for Creation of a National PAD Public Awareness Program: An Opportunity to Improve Cardiovascular Health. J Vasc Surg 2004;39:474-81 (co-published in: J Vasc Endovasc Surg; J Vasc Nursing; J Vasc Interventional Radiol; Vascular Medicine; International Angiology; Angiology; Endovascular Today)
Hirsch AT, Duprez D. The Potential Role of Angiotensin Converting Enzyme Inhibition in Peripheral Arterial Disease. Vascular Medicine 2004; 9:1–6
Ringleb PA, Bhatt DL, Hirsch AT, Topol EJ, Hacke W, on behalf of the CAPRIE Investigators. Benefit of clopidogrel over aspirin is amplified in patients with a history of ischemic events. Stroke 2004;35:528-532
Bittl JA, Hirsch AT. Clinician Update: Concomitant Peripheral Arterial Disease and Coronary Artery Disease; Therapeutic Opportunities. Circulation 2004;109;3136-3144
Mohler ER, Treat-Jacobson, D, Reilly MP, Cunningham KE, Miani M Criqui M, Hiatt WR, Hirsch AT. Utility and Barriers to Performance of the Ankle-Brachial Index in Primary Care Practice. Vascular Medicine 2004, Vascular Medicine 2004;9:253-260.
Treesak C, Kasemsup V, Treat-Jacobson D, Nyman JA, Hirsch AT. Cost-Effectiveness of Exercise Training to Improve Claudication Symptoms in Patients with Peripheral Arterial Disease. Vascular Medicine 2004;9:279-285
Wattanakit K, Folsom AR, Selvin E, Weatherly E, Pankow J, Brancati FL, Hirsch AT. Risk Factors for Peripheral Arterial Disease Incidence in Persons with Diabetes: the Atherosclerosis Risk in Communities (ARIC) Study. Atherosclerosis 2005;180:389–397
Wattanakit K, Williams JE, Schreiner PJ, Hirsch AT, Folsom AR. Association of Anger Proneness, Depression, and Low Social Support with Peripheral Arterial Disease: the Atherosclerosis Risk in Communities (ARIC) Study. Vascular Medicine 2005 Aug;10(3):199-206.
Hirsch AT, Haskal ZJ, Hertzer NR, et al. ACC/AHA Guidelines for the management of patients with peripheral arterial disease (lower extremity, renal, mesenteric, and abdominal aortic): A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Develop Guidelines for the Management of Patients with Peripheral Arterial Disease [Lower Extremity, renal, Mesenteric, and Abdominal Aortic]). Circulation 2006 113: 1474 - 1547; and J Am Coll Cardiol, 2006; 47:1239-1312.
Bhatt DL, Steg PG, Ohman EM, Hirsch AT, Ikeda Y, Mas JL, Goto S, Liau CS, Richard AJ, Röther J, and Wilson PF, on behalf of the REACH Registry Investigators. International Prevalence, Recognition, and Treatment of Cardiovascular Risk Factors in Outpatients with Atherothrombosis. JAMA. 2006;295:180-189
Ohman EM, Bhatt DL, Steg PG, Goto S, Hirsch AT, Liau CS, Mas JL, Richard AJ, Röther J, and Wilson PWF, on behalf of the REACH Registry Investigators. The REACH Registry, an international, prospective, observational investigation in subjects at risk of atherothrombotic events – study design. Am Heart J. 2006 Apr;151(4):786.e1-10.
Hirsch AT. The Treatment of Peripheral Arterial Disease - Extending "Intervention" to "Therapeutic Choice". New England J Med 2006 354;18:1944-1947
Hirsch AT. Critical Limb Ischemia and Stem Cell Research: Anchoring Hope with Informed Adverse Event Reporting. Circulation 2006; Circulation. 2006;114:2581-2583
Wattanakit K, Folsom AR, Duprez DA, Weatherley BD, Hirsch AT. Clinical Significance of a “High” Ankle-Brachial Index: Insights from the Atherosclerosis Risk in Communities (ARIC) Study. Atherosclerosis 2007;190(2);459-464.
Steg G, Bhatt DL, Wilson PWF, D’Agostino R, Ohman EM, Rother J, Liau CS, Hirsch AT, Mas JL, Ikeda Y, Pencina MJ, Goto S, for the REACH Registry Investigators. One-Year Cardiovascular Event Rates in Outpatients With Atherothrombosis. JAMA. 2007;297:1197-1206
Collins TC, Beyth RJ, Petersen NJ, Suarez-Almazor M, Bush RL, Hirsch AT, Ashton CM. Process of Care and Ischemic Limb Outcomes in Peripheral Arterial Disease. J Gen Intern Med. 2007 Jul;22(7):942-8. Epub 2007 Apr 24.
Korcarz CE, Hirsch AT, Bruce C, DeCara JM, Mohler ER, Pogue B, Postley J, Tzou WS, Stein JH. Carotid Intima-Media Thickness Testing by Non-Sonographer Clinicians: The Office Practice Assessment of Carotid Atherosclerosis (OPACA) Study. J Am Soc Echocardiogr. 2007 Sep 27;
Hirsch AT, Murphy TP, Lovell MB, Twillman G, Treat-Jacobson D, Harwood E, Mohler ER, Creager MA, Hobson RW, Robertson RM, Howard WJ, Criqui MH. Gaps in Public Knowledge of Peripheral Arterial Disease: The First National PAD Public Awareness Survey. Circulation. 2007 Oct 30;116(18):2086-94.
Regensteiner JG, Hiatt WR, Coll JR, Criqui MH, Treat-Jacobson D, McDermott MM, Hirsch AT. The Impact of Peripheral Arterial Disease on Health-Related Quality of Life in the Peripheral Arterial Disease Awareness, Risk, and Treatment: New Resources for Survival (PARTNERS) Program. Vascular Medicine 2008 Feb;13(1):15-24.
Hirsch AT, Hartman L, Town RJ, Virnig BA. National Healthcare Costs of Peripheral Arterial Disease in the USA Medicare Population. Vascular Medicine 2008 Aug;13(3):209-15.Murphy TP, Hirsch AT, Cutlip DE, Mohler E, Regensteiner JG, Cohen DJ, Massaro J, Lewis BA, Jaff MR, Sopko G, Cerezo J, Oldenburg N, Steffes MW, Goldberg SH, Ershow AG. The National Institutes of Health CLEVER Study (Claudication: Exercise Vs. Endoluminal Revascularization): Rationale and Methods. J Vasc Surg. 2009 Oct;50(4):942-945.e2. Epub 2009 Aug 5.
Bronas UG, Hirsch AT, Murphy T, Badenhop D, Collins TC, Ehrman JK, Ershow AG, Lewis B, Treat-Jacobson DJ, Walsh ME, Oldenburg N, Regensteiner JG.Design of the multicenter standardized supervised exercise training intervention for the 'CLaudication: Exercise Vs Endoluminal Revascularization (CLEVER) study'. Vasc Med. 2009 Nov;14(4):313-21.
Lovell M, Harris K, Forbes T, Twillman G, Abramson B, Criqui MH, Schroeder P, Mohler ER 3rd, Hirsch AT; Peripheral Arterial Disease Coalition. Peripheral arterial disease: lack of awareness in Canada. Can J Cardiol. 2009 Jan;25(1):39-45.
Alberts MJ, Bhatt DL, Mas JL, Ohman EM, Hirsch AT, Röther J, Salette G, Goto S, Smith SC Jr, Liau CS, Wilson PW, Steg PG; REduction of Atherothrombosis for Continued Health Registry Investigators. Three-year follow-up and event rates in the international REduction of Atherothrombosis for Continued Health Registry. Eur Heart J. 2009 Oct;30(19):2318-26. Epub 2009 Aug 31. |
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Professional Experience:
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1999-2004, Vascular Disease Foundation, Founding President (1999-2003)
2002-2005, Chair, American College of Cardiology-American Heart Association Writing Committee for Peripheral Arterial Disease Management Guidelines
2002-2004, Cardiac and Renal Drugs Advisory Committee, Food and Drug Administration
1995-2006, International Union of Angiology; Executive Board (2004-2006)
1996-present, Peripheral Vascular Disease Committee, American College of Cardiology
2005-2009, Chair, Peripheral Arterial Disease Coalition
2005-present, Steering Committee, American Heart Association Council for Peripheral Vascular Diseases. See:
http://pt.wkhealth.com/pt/re/pvd/home.htm;jsessionid=K2gS35ppZGkX02GT7pDLwL4HhZCTqqvysgrScFKn13LwvVqqBj1m!-901315139!181195629!8091!-1
2006-present, Professional Education Committee, American Heart Association
2006-present, Co-chair, Intersocietal PAD Guidelines Implementation Task Force
2008-present, American College of Cardiology Advocacy Committee
2007-present, ACC/AHA/ACR/SCAI/SIR/SVMB/SVN Writing Committee to Develop Clinical Data Standards for Peripheral Arterial Disease
2007-present, ACC/AHA/ACR/SCAI/SIR/SVMB/SVN Peripheral Arterial Disease Performance Measures Writing Committee
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Honors:
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Community Partners Recognition Award, University of Minnesota School of Public Health, 2004
“Master of the Society for Vascular Medicine”, 18th Annual Scientific Sessions of the Society for Vascular Medicine, June 8, 2007
“President’s Award” of the Vascular Disease Foundation, 2008
"Vision Award" of the Vascular Disease Foundation, 2009 |
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Mailing Address:
Division of Epidemiology & Community Health
1300 South Second Street, Suite 300
Minneapolis, MN 55454
Phone:(612) 626-1152
Email: hirsc005@umn.edu
Office: 425
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Link
to: Academic Health Center : School
of Public Health : U of M Home 
